Synchronization of Purkinje cell pairs along the parallel fiber axis: a model

Sergio Solinas, Reinoud Maex, Erik De Schutter Sergio Solinas, Reinoud Maex and Erik De Schutter

Laboratory of Theoretical Neurobiology, Born-Bunge Foundation, University of Antwerp-UIA, Universiteitsplein 1, Antwerp 2610, Belgium

Abstract

We build a detailed model of the cerebellar molecular layer taking into account the anatomical, morphological and physiological data available to date. Based on how the percentage of input shared by nearby Purkinje cells (PCs) depends on their relative position in the PC layer we conclude that shared inhibition must play a crucial role in PC synchronization.

Keywords: Cerebellum; Purkinje cells; Synchrony; Interneuron; Inhibition

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